报告题目：Single-Nanoparticle Sensors of Nano-bio Interactions

报 告 人：Prof. Teri W. Odom

美国西北大学化学系主任、ACS Photonics执行主编

报告时间：2019年7月2日 下午 14:00-15:00

报告地点：无机超分子楼一楼报告厅

Nanotechnology offers new strategies for minimally invasive and localized approaches to diagnose and treat diseases. For example, nanoparticles have been explored in a range of applications, including as drug delivery vehicles, imaging probes, and therapeutic agents. Although increased therapeutic efficacy has been realized, direct visualization of how engineered nanoparticles interact with specific organelles or cellular components has seen limited attention. Such interactions will have implications for fundamentals in cancer biology as well as in the design of translational therapeutic agents. This talk will describe how drug-loaded gold nanostars can behave as multi-spectral optical probes for interrogating how therapeutic nanoconstructs interact with cells at the nanoscale. We will focus on model cancer cell systems that can be used to visualize how gold nanostar nanoconstructs target cells, rotate on the plasma membrane, are endocytosed, and are trafficked intracellularly. We will also discuss mechanisms of cell death associated with these unique therapeutic nanoconstructs.

Teri W. Odom is Charles E. and Emma H. Morrison Professor of Chemistry and Chair of the Chemistry Department at Northwestern University. She is an expert in designing structured nanoscale materials that exhibit extraordinary size and shape-dependent optical properties. Odom has pioneered a suite of multi-scale nanofabrication tools that has resulted in flat optics that can manipulate light at the nanoscale and beat the diffraction limit, plasmon-based nanoscale lasers that exhibit tunable color, and hierarchical substrates that show controlled wetting and super-hydrophobicity. She has also invented a class of biological nanoconstructs that are facilitating unique insight into nanoparticle-cell interactions and that show superior imaging and therapeutic properties because of their gold nanostar shape.She is on the Editorial Advisory Boards of ACS Nano, Materials Horizons, Annual Reviews of Physical Chemistry, ChemNanoMat, Bioconjugate Chemistry, and Nano Letters. She was founding Associate Editor for Chemical Science (2009-2013) and serves as founding Executive Editor of ACS Photonics (2013 - ). Odom’s Personal Story of Discovery was featured by ACS Publications.