报告题目： Construction of metalloenzymes: coordination chemistry and catalytic activities in proteins

报告人 ：Yoshihito Watanabe（渡边芳人 教授）

报告时间：2016年9月15日下午15:00

报告地点：超分子楼 二楼圆形报告厅

摘要：  Based on catalytic reactions, coordination chemistry, and organometallic chemistry, we are able to design enzymes which catalyze nobel reactions such as oxidation, hydrogenation, C-C coupling, and polymerization.

关键词：Keywords   Catalytic Chemistry, Metal Complex, Organometallic Chemistry, Mutation, Oxidation, Reduction, Suzuki Coupling, polystyrene, Myoglobin, Heme Enzyme, Ferritin

主要经历：

1972 - 1976 B.Sc. Tohoku University

1977 - 1982 Dr. Sc. Tsukuba University

1982 Postdoctoral Fellow, University Michigan

1985  Res. Staff Member, Princeton University, Princeton, NJ, USA

1987  Assistant Professor, School of Medicine, Keio University

1990  Associate Professor, Kyoto University

1994  Professor, Institute for Molecular Science

2002 - present  Professor, Nagoya University

2009 - present vice-President, Nagoya University

主要成果：

Y. Watanabe et al. "Inhibition of Heme Uptake in Pseudomonas aeruginosa by its Hemophore (HasAp) Bound to Synthetic Metal Complexes," Angew. Chem. Int. Ed.,53, 2862–2866 (2014).

Y. Watanabe et al. "Highly Selective Hydroxylation of Benzene to Phenol by Wild-type Cytochrome P450BM3 Assisted by Decoy Molecules," Angew. Chem. Int. Ed.,52, 6606-6610 (2013).

Y. Watanabe et al. “Crystal Structure of H₂O₂-Dependent Cytochrome P450_SPα with its Bound Fatty Acid Substrate: Insight into the regioselective hydroxylation of fatty Acids at the α Position,” J. Biol. Chem., 286, 29941-29950 (2011).

Y. Watanabe et al. "Reactivities of Oxo and peroxo Intermediates Studied by Hemoprotein Mutants," Acc. Chem. Res., 40, 554-562 (2007).