报告题目：Poly(2-oxazoline) Based Nanoformulations with Superior Safety and Efficacy In Vivo
报告人：Prof. Rainer Jordan
             Chair of Macromolecular Chemistry, Technische Universit?t Dresden 
报告时间：2016年9月7日上午09：30 (星期三)
报告地点：无机超分子楼一楼圆形报告厅

报告摘要：

The poor solubility of many anticancer drugs including paclitaxel (PTX), the commercially most successful anticancer drug, has long been hampering the development of suitable formulations. Here, we report on a nanoformulation of PTX with a poly(2-oxazoline) triblock copolymer (POx), which is characterized by a facile preparation, extraordinary high drug loading of 50 % wt. and PTX solubility of up to 45 g/L that calculates to a solubility increase by a factor of 50.000. The formulation shows excellent shelf stability and defined, sub-100 nm size spherical micelles. We observe favorable in vitro and in vivo safety profiles and a higher maximum tolerated dose as compared to PTX formulations currently used in chemotherapy. Pharmacokinetic analysis reveals that the higher dose administered leads to a higher exposure of the tumor to PTX. As a result, we observed a dramatically improved therapeutic outcome in orthotopic tumor models including the very aggressive “T11” mouse claudin-low breast cancer orthotopic, syngeneic transplants which is considered as a clinical faithful cancer model.
报告人简介：
Since 2009  Professor (W3), Chair of Macromolecular Chemistry, TU Dresden
2004 - 2008  Assistant Professor (Akadem. Oberrat), TU München
1999 - 2004  Habilitation, TU München with Prof. Oskar Nuyken, Lehrstuhl für Makromolekulare Stoffe
1998 - 2008 Assistant Professor, Polytechnic University, Brooklyn, NY, USA
1996 - 1998  DFG-PostDoc-Fellow at Polytechnic University, Brooklyn, NY with Prof. Abraham Ulman
1993 - 1996 Dr. rer. nat. in Chemistry at the Univ. Mainz and C.N.R.S., Paris, France
1989 - 1990 IAS Fellow at Kyoto University, Japan
1986 - 1993 Study of Chemistry (Dipl. Chem.) at the Universit?t Mainz, Germany

研究领域
Organic chemistry, Polymer chemistry, Surface chemistry and physics, Living and controlled polymerizations, Nanomedicine, Regenerative Therapies, Biomaterials, Polymers for opto-electronics

荣誉奖励
2012 Elkin-Lecture of the Winship Cancer Institute
2000 Dr. Herrmann Schnell Prize of the GDCh
1996 DFG-PostDoc Fellow
1993 DAAD-PROCOPE Fellow
1989 IAS Fellow of the DAAD

发表文章
(>160 publications in referred journals, >150 invited lectures, 7 patents, h-Index ≧ 47, citations≧6000)

[1] F. Manzenrieder, R. Luxenhofer, M. Retzlaff, R. Jordan, M. G. Finn, Stabilization of Virus-Like Particles with Poly(2-oxazoline)s Angew. Chem. Int. Ed. 2011, 50, 2601-2605.
[2] M. Steenackers, A. M. Gigler, N. Zhang, F. Deubel, M. Seifert, L. H. Hess, C. H. Y. X. Lim, K. P. Loh, J. A. Garrido, R. Jordan, M. Stutzmann, I. D. Sharp, Polymer Brushes on Graphene J. Am. Chem. Soc. 2011, 133, 10490-10498.
[3] A. Schulz, S. Jaksch, R. Schubel, E. Wegener, Z. Di, Y. Han, A. Meister, J. Kressler, A. V. Kabanov, R. Luxenhofer, C. M. Papadakis, R. Jordan, Drug-Induced Morphology Switch in Drug Delivery Systems Based on Poly(2-oxazoline)s ACS Nano 2014, 8, 2686-2696.
[4] T. Zhang, Y. Du, J. Kalbacova, R. Schubel, R. D. Rodriguez, T. Chen, D. Zahn, R. Jordan, Wafer-scale Synthesis of Defined Polymer Brushes under Ambient Conditions Polym. Chem. 2015, in print.
[5] D. Hafner, L. Ziegler, M. Ichwan, T. Zhang, M. Schneider, M. Schiffmann, C. Thomas, K. Hinrichs, R. Jordan, I. Amin, Mussel-inspired polymer carpets: direct photografting of polymer brushes on polydopamine nanosheets for controlled cell adhesion Adv. Mater. 2016, in print.

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