报告题目：Marine Macrocycles Phorboxazole & Largazole from Total Synthesis

                to Therapeutic Agents Development

报告人：   王 博 研究员，中科院引进国外杰出人才

                中国科学院长春应用化学研究所

报告时间：2014年11月28日下午15：00（星期五）

报告地点：唐敖庆楼408报告厅

简历： 2002. 07 — 2006. 12 Ph.D., University of Minnesota

           1996. 09 — 2000. 07 理学学士，吉林大学化学系基地班

             Abstract : Phorboxazoles and largazole are marine macrocyclic compounds isolated from Indian Ocean sponge Phorbos sp. and Floridian marine cyanobacterium Symploca sp. respectively. Both natural products were reported to exhibit highly potent antiproliferative activity against various cancer cell lines. More interestingly, remarkable levels of selective inhibition of cancer cell growth over non-transformed cells was observed for largazole via the inhibition of histone deacetylase, while the mode of action of phorboxazoles remained unknown for their S phase cytostatic effects on cancer cells. Attracted by their condensed challenging structural features and biological significance, we have embarked upon the development of a practical and scalable total synthesis to phorboxazoles, largazole and their analogues. The details of the total synthesis efforts by novel synthetic methodology and strategy development will be highlighted.