报告题目：The foundation of molecular medicine: A chemical biology approach

报告人：谭蔚弘 博士

时间：2014年9月26日下午15:00-16:00

地点：麦氏楼二楼圆形报告厅

报告人简介：

Professor Weihong Tan received his Ph.D. in Physical Chemistry from the University of Michigan, Ann Arbor, in 1993. He is currently a Distinguished Professor of Chemistry and Biomedical Engineering and the Director of the State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University. Tan’s group has developed research programs in chemical biology, bionanotechnology, bioanalysis and biomedical engineering. Currently, the Tan group is working on a variety of nucleic acid probes for biomedical studies and developing new nanomaterials and bionanotechnologies for bioanalysis, molecular imaging and drug delivery. Most importantly, the Tan group has pushed forward a coordinated effort to elucidate the molecular foundation of such intractable diseases as cancer by using a chemical biology approach. His work has been recognized by such prestigious organizations as Pittcon and the American Chemical Society. Tan has published extensively in the field of chemical biology, molecular engineering, bioanalytical chemistry and bionanotechnology, accumulating more than410 papers to his credit with an H-index of 86 and more than 22,100 citations. He is one of the 198 people world-wide selected as Highly Cited Researchers for the last 11 years (The world’s Most Influential Scientific Minds 2014). He is currently the Associate Editor for ACS Analytical Chemistry.

Selected Publications for 2014

1.           Kwame Sefah , Zunyi  Yang , Kevin M Bradley , Shuichi  Hoshika , Elizabeth  Jimenez , Liqin  Zhang , Guizhi  Zhu , Savita  Shanker , Fahong Yu , Weihong  Tan and Steven  A.  Benner, SELEX with Artificial Expanded Genetic Information Systems (AEGIS). In Vitro Selection of AEGIS DNA Aptamers against Cancer Cells, Proceedings of  the National Academy of Sciences USA, 2014, 111, 1449-1454.

2.           Rong Hu, Xiaobing Zhang, Zilong Zhao, Guizhi Zhu, Tao Chen, Ting Fu and Weihong Tan, DNA Nanoflowers for Multiplexed Cellular Imaging and Traceable Targeted Drug Delivery, Angewandte Chemie, International Edition, 2014, 53, 5821-5826. 

3.           RuoWen Wang, Guizhi Zhu, Lei Mei, Yan Xie, Haibin Ma, Mao Ye, Feng-Ling Qing, and Weihong Tan, Molecular Train: Automated and Modular Synthesis of Aptamer-Drug Conjugates for Targeted Drug Delivery, Journal of the American Chemical Society, 2014, 136, 2731.

4.           Mingxu You, Lu Peng, Na Shao, Liqin Zhang,  Liping Qiu, Cheng Cui and Weihong Tan, DNA “Nano-Claw”: Logic-based Autonomous Cancer Targeting and Therapy, Journal of the American Chemical Society, 2014, 136, 1256-1259.

5.           Zilong Zhao, H. Fan, G. Zhou, H. Bai, Hao Liang, Xiaobing Zhang and Weihong Tan, Activatable NIR fluorescence/MRI bimodal platform for tumor cell imaging via MnO₂ nanosheet-aptamer nanoprobe, Journal of the American Chemical Society, 2014, 136, 11220-11223.

6.           Liyi Zhou, Qianqian Wang, Xiaobing Zhang, Yifan Lv, Guojiang Mao, Aili Luo, Yongxiang Wu, Yuan Wu, Jing Zhang and Weihong Tan, Molecular Engineering of a TBET-based Two-Photon Fluorescent Probe for Ratiometric Imaging of Living Cells and Tissues, Journal of the American Chemical Society, 2014, 136, 9838-9841.

7.           Liping Qiu, Tao Zhang, C. Wu, G. Zhu, M. You, Jianhui Jiang, Ruqin Yu and Weihong Tan, Biochemical Sensors Self-Anchored onto Cell Membranes for Real-Time Monitoring of  the Cellular Microenvironment, Journal of the American Chemical Society, 2014, 136,.

8.           Zhi-Ling Song, Xia Bian, Li-Yi Zhou, Ding Ding, Hao Liang, Yu-Xiu Zou, Shan-Shan Wang, Long Chen, Xiao-Bing Zhang, Zhuo Chen and Weihong Tan, Alkyne-Functionalized Superstable Graphitic Silver Nanoparticles for Raman Imaging, Journal of the American Chemical Society, 2014, 136, .

9.           Yuan Liu, Tao Chen, C. Wu, L. Qiu, Rong Hu, J. Li, S. Cansiz, Liqin Zhang, Cheng Cui, Guizhi Zhu,  Mingxu You, Tao Zhang, Weihong Tan, Facile Surface Functionalization of Hydrophobic Magnetic Nanoparticles, Journal of the American Chemical Society, 2014, 136, 12552.

10.        Da Han, Mingxu You, Tao Zhang, Tao Chen, Liping Qiu, Cuichen Wu, Zheng Zheng and Weihong Tan, Acquired Immune System Biomimicry with DNA-Enzyme Cascade Network, Nature Chemistry, 2014, revision.

11.        Xia Bian,  Zhi-Ling Song, Yu Qian, Wei Gao, Zhen-Qian Cheng, Long Chen, Hao Liang, Ding Ding, Xiang-Kun Nie, Zhuo Chen and Weihong Tan, Fabrication of Graphene-isolated-Au-nanocrystal Nanostructures for Multimodal Cell Imaging and Photothermal-enhanced Chemotherapy, Scientific Reports, 2014, 4, 6093.

12.        RuoWen Wang, C. Wang, Yang Cao, Zhi Zhu, Chaoyong Yang, Jianzhong Chen, Feng-Ling Qing and Weihong Tan, Trifluoromethylated nucleic acid analogues capable of self-assembly through hydrophobic interactions, Chemical Science, 2014, 5(10), 4076 – 4081.

13.        Hao Liang, Xiao-Bing Zhang, Y Lv, Liang Gong, R Wang, X Zhu, R Yang and Weihong Tan, Functional DNA-assembled Nanomaterials: Cellular Applications in Biosensing, Imaging and Targeted Therapy, Accounts of Chemical Research , 2014, 47, 1891-1901. 

14.        Qiaoling Liu, Jin Chen, Yanyue Wang, Xiaohong Fang, Xiaobing Zhang, Zhuo Chen and Weihong Tan, Aptamer-conjugated nanomaterials for specific cancer cell recognition and targeted cancer therapy, NPG Asia Materials, 2014, 6, e95.

15.        Lu Peng, Mingxu You, Cuichen Wu, Da Han, Ismail ??soy, Tao Chen, Zhuo Chen and Weihong Tan, Reversible phase transfer of nanoparticles based on photoswitchable host-guest chemistry, ACS Nano, 2014, 8, 2255-2561.

16.        Hong-Min Meng, Xiaobing Zhang, Yifan Lv, Zilong Zhao, Nan-Nan Wang, Ting Fu, H. Fan, Hao Liang, Liping Qiu, Guizhi Zhu, and Weihong Tan, DNA Dendrimer: An Efficient Nanocarrier of Functional Nucleic Acids for Intracellular Molecular Sensing, ACS Nano, 2014, 8, 6171-6181.

17.        Fujian Huang, H Xu, Weihong Tan and H Liang, Multicolor and Erasable DNA Photolithography, ACS Nano, 2014, 8, 6849-6855.

18.        Chunmei Li, Tao Chen, Ismail Ocsoy, Guizhi Zhu, Emir Yasun, Mingxu You, Cuichen Wu, Jing Zheng, Erqun Song, Cheng Zhi Huang and Weihong Tan, Gold-Coated Fe₃O₄ Nanoroses with Five Unique Functions for Cancer Cell Targeting, Imaging and Therapy, Advanced Functional Materals, 2014, 24, 1772-1780.

19.        Baosheng Guo, Baoting Zhang, L Zheng, Tao Tang, Jin Liu, H Wu, Zhijun Yang, Songlin Peng, Xiaojuan He, Hongqi Zhang, Kevin K.M. Yue, Fuchu He, Lingqiang Zhang, Ling Qin, Zhaoxiang Bian, Weihong Tan, Zicai Liang, Aiping Lu, Ge Zhang, Therapeutic RNA Interference Targeting CKIP-1 with a Cross-Species Sequence to Stimulate Bone Formation, Bone, 2014, 59, 76-88.

20.        Da Han, Huaizhi Kang, Tao Zhang, Cuichen Sam Wu, Cuisong Zhou, Mingxu You, Zhuo Chen, Xiaobing Zhang and Weihong Tan, Nucleic Acid-Based Logical Systems, Chemistry, A European Journal, 2014, 20, 2866-73.  

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